Since the Sandy Bridge/P67 era, MSI has deployed an interactive "Click BIOS" UEFi GUI interface for their bios thats allows the use of the mouse and other advanced features like taking screenshots, loading/saving profiles and an integrated web browser. We felt that the screen real estate could still be better utilized (like on recent ASUS/Gigabyte boards) and some option labels made less ambiguous. Overall, it was responsive and didn't cause our testers much frustration.
Central to the Z77A-GD65 is MSI's Control Center utility, a palatable 8MB utility which offers all the essential overclocking knobs and information in a non-nonsense fashion.
Other than the THX TruStudio Pro that we've mentioned early, MSI also included the Lucid VIRTU MVP software which improves performance in certain benchmarks and games.
With a Core i5-3570K and 2 x 8GB G.Skill 2400MHz DDR3 kit installed, the auto overclocking feature took us to a conservative 4.2GHz and only 2133Mhz on the rams (strange that it didn't use XMP support).